Stem Cell and Advanced Biomedicine Lab at SMWU 숙명여자대학교 줄기세포 첨단바이오의약연구실

Publications

2026

Defective autophagy in GNE myopathy is rescued by inhibition of noncanonical Akt-mTORC1 activation across multiple isogenic models.
Dong-Woo Kim, Eun-Ji Kwon, Hyuk Kwon, Jumee Kim, Hyuk-Jin Cha
Experimental & molecular medicine  ·  01 Jan 2026  ·  doi:10.1038/s12276-026-01701-7

2025

Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
Beom‐Ki Jo, Seung‐Yeon Lee, Hee‐Ji Eom, Jumee Kim, Hyuk‐Jin Cha
AGING CELL  ·  01 Jan 2025  ·  doi:10.1111/acel.70268
Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming
Beom-Ki Jo, Young Seok Song, Woohyun Song, Hee-Ji Eom, Yon Jae Lee, Jumee Kim, Seunghee Hong, Seung-Woo Cho, Hyuk-Jin Cha
Unknown  ·  01 Jan 2025  ·  doi:10.1101/2025.11.03.686120

2024

Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity
Jumee Kim, Eun-Ji Kwon, Yun-Jeong Kim, Dayeon Kim, Yoon-Ze Shin, …, Hyoung Doo Shin, Lyoung Hyo Kim, Mi-Ok Lee, Young-Hyun Go, Hyuk-Jin Cha
CELLULAR AND MOLECULAR LIFE SCIENCES  ·  01 Jan 2024  ·  doi:10.1007/s00018-023-05060-8

2023

Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction
Jumee Kim, Somi Kim, Seung-Yeon Lee, Beom-Ki Jo, Ji-Young Oh, …, Jae-Seok Roe, Chang Pyo Hong, Jong Kyoung Kim, Bon-Kyoung Koo, Hyuk-Jin Cha
SCIENCE ADVANCES  ·  01 Jan 2023  ·  doi:10.1126/sciadv.adi8454
MutSa and MutSb as size-dependent cellular determinants for prime editing in human embryonic stem cells
Ju-Chan Park, Yun-Jeong Kim, Jun Hee Han, Dayeon Kim, Mihn Jeong Park, Jumee Kim, Hyeon-Ki Jang, Sangsu Bae, Hyuk-Jin Cha
MOLECULAR THERAPY-NUCLEIC ACIDS  ·  01 Jan 2023  ·  doi:10.1016/j.omtn.2023.05.015

2022

Multiple isogenic GNE-myopathy modeling with mutation specific phenotypes from human pluripotent stem cells by base editors
Ju-Chan Park, Jumee Kim, Hyun-Ki Jang, Seung-Yeon Lee, Keun-Tae Kim, …, Hee-Jung Choi, Soon-Jung Park, Sung-Hwan Moon, Sangsu Bae, Hyuk-Jin Cha
BIOMATERIALS  ·  01 Jan 2022  ·  doi:10.1016/j.biomaterials.2022.121419
High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells
Ju-Chan Park, Hyeon-Ki Jang, Jumee Kim, Jun Hee Han, Youngri Jung, Keuntae Kim, Sangsu Bae, Hyuk-Jin Cha
MOLECULAR THERAPY NUCLEIC ACIDS  ·  01 Jan 2022  ·  doi:10.1016/j.omtn.2021.11.023
Fat3 regulates neural progenitor cells by promoting Yap activity during spinal cord development
Soyeon Seo, Young A. Kim, Junekyoung Lee, Seunghwan Lee, Jumee Kim, Seunghee Lee
SCIENTIFIC REPORTS  ·  01 Jan 2022  ·  doi:10.1038/s41598-022-19029-3

2020

Safe scarless cassette-free selection of genome-edited human pluripotent stem cells using temporary drug resistance
Keun-Tae Kim, Ju-Chan Park, Hyeon-Ki Jang, Haeseung Lee, Seokwoo Park, …, Yan Jin, Wankyu Kim, Jeongmi Lee, Sangsu Bae, Hyuk-Jin Cha
BIOMATERIALS  ·  01 Jan 2020  ·  doi:10.1016/j.biomaterials.2020.120295
Luteolin Induces Selective Cell Death of Human Pluripotent Stem Cells
Young-Hyun Go, Jumee Kim, Ho-Chang Jeong, Seong-Min Kim, Yun-Jeong Kim, Soon-Jung Park, Sung-Hwan Moon, Hyuk-Jin Cha
BIOMEDICINES  ·  01 Jan 2020  ·  doi:10.3390/biomedicines8110453

2018

Rnf220 cooperates with Zc4h2 t o specify spinal progenitor domains
Jumee Kim, Tae-Ik Choi, Shinhye Park, Myung Hee Kim, Cheol-Hee Kim, Seunghee Lee
DEVELOPMENT  ·  01 Jan 2018  ·  doi:10.1242/dev.165340